New Delhi, Sep 15
A higher weekly dose of semaglutide (7.2 mg) is safe and can significantly improve weight loss in adults living with obesity, including those with type 2 diabetes (T2D), according to an international study, published on Monday.
The findings, based on results of two large-scale, international phase 3 clinical trials and published in The Lancet Diabetes & Endocrinology journal, suggest that a higher dose of semaglutide offers a promising new option for people who have not achieved sufficient weight loss with existing treatments.
“The currently approved dose of semaglutide is 2.4 mg, and the study showed 7.2 mg is safe and leads to additional weight reduction,” said the researchers, including those from Canada, the US, Denmark, Norway, and Portugal.
In adults without diabetes, a 7.2 mg dose of semaglutide led to an average weight loss of nearly 19 per cent, surpassing the 16 per cent loss seen with 2.4 mg and 4 per cent with placebo.
Nearly half of the participants on the higher dose lost 20 per cent or more of their body weight, with about one-third losing at least 25 per cent.