Australian researchers have launched a pioneering clinical trial that aims to combat aggressive cancers previously deemed untreatable.

The trial led by a team from the Australian National University (ANU) focussed on malignancies driven by the elusive MYC protein -- a protein implicated in 70 per cent of human cancers --, news agency reported.

The success of the trial could redefine treatment paradigms for aggressive malignancies globally, offering a template for tackling other molecularly complex diseases, said the team.

The study will test an experimental drug, PMR-116, designed to disrupt cancer growth mechanisms in patients with prostate, breast, ovarian, and blood cancers, or MYC-driven tumours.

Actress Sharvari's birthday got a little more special as she has been roped in as the leading lady for Imtiaz Ali's next.

Sharing her excitement for a new journey, the 'Maharaja' actress revealed that she has been manifesting to work with the 'Tamasha' maker ever since she decided to become an actor.

The birthday star penned on her official Instagram account, "What an incredible surprise to see this announcement happen on my birthday! Best birthday ever! @imtiazaliofficial sir, I have manifested to be directed by you ever since I’ve dreamt to be an actor.. This will be the most amazing learning experience for me.. It is an honour to be a part of your vision… Thank you for choosing me .. It feels so special to be a part of this dream team @naseeruddin49 @diljitdosanjh @vedangraina. Eeeeppp!!! So excited for this new journey."

This yet-to-be-titled project enjoys a stellar cast featuring Diljit Diljit, Naseeruddin Shah, Vedang Raina, and Sharvari. It is believed that the film will go on floors by August this year and will reach the cinema halls on Baisakhi 2026.

The Indian men's hockey team suffered another heartbreak as they slumped to defeat despite taking a 2-0 lead as the Kookaburras bounced back to prevail 3-2 in the ongoing FIH Hockey Pro League 2024/25 here in Antwerp on Saturday.

Following four successive narrow losses in the European leg, the Indian team, sans their captain Harmanpreet Singh, had a dream start against Australia until they floundered in the final quarter, allowing their opponents to come back. It was goals by Nathan Ephraums (42'), Joel Rintala (56'), and Tom Craig (60') that put Australia ahead, while Abhishek (8', 35') scored a double for India.

It was an entertaining opening quarter with India taking the lead as early as the eighth minute of the game. The initial few minutes saw both teams trade chances in the circles until a perfect pass from the midfield by Manpreet Singh, who is on 399 international caps, to Abhishek positioned at the top of the circle fetched India a crucial 1-0 lead.

The Israeli Defence Forces (IDF) on Saturday announced elimination of nine Iranian nuclear scientists during the opening phase of its military operation against Iran's nuclear programme, which began early Friday.

Revealing details of the ongoing operation, the IDF described it as a critical blow to Iran's nuclear ambitions.

According to the IDF, the nine scientists were instrumental in advancing Iran's efforts to acquire a nuclear weapon.

"All the scientists and experts who were eliminated were significant sources of knowledge in the Iranian nuclear project and had decades of cumulative experience in the development of nuclear weapons," the military stated.

Those killed in the strikes were identified as Fereydoon Abbasi, a nuclear engineering expert; Mohammad Mehdi Tehranchi, a physicist; Akbar Motalebi Zadeh, a chemical engineering expert; Saeed Barji, an expert in materials engineering; Amir Hassan Fakhahi, a physicist; Abd al-Hamid Minoushehr, an expert in reactor physics; Mansour Asgari, a physicist; Ahmad Reza Zolfaghari Daryani, a nuclear engineer; and Ali Bakhouei Katirimi, a mechanical expert.

Manipur Police have seized a huge quantity of highly-addictive methamphetamine tablets valued at over Rs 22 crore and arrested a truck driver, officials said here on Saturday.

A senior official said that the Manipur Police intercepted a truck at New Keithelmanbi Police picket in Imphal West District on Friday night and found huge amounts of drugs concealed inside the roof of the vehicle.

The contraband items were found to be methamphetamine tablets, also known as Yaba or party tablets, upon sample testing.

Accordingly, the driver of the truck, identified as Nawaj Sharif (34), a resident of Thoubal District was arrested and 57.285 kg of methamphetamine tablets worth Rs 22 crore were seized, the official said.

Another police officer said that last week a joint team of the Directorate of Revenue Intelligence (DRI), Customs, Assam Rifles, and the Manipur Police seized 7,755.75 grams of heroin valued at Rs 54.29 crore and 6,736 grams of opium valued at Rs 87.57 lakh in the international grey drug market, along with Rs 35.63 lakh cash.

Alcohol-related liver disease deaths are increasing rapidly among women and young adults, according to new research.

Researchers from the Universities Havard, Stanford, and Southern California (USC) attributed the rise to higher drinking during the Covid-19 pandemic, as well as to increasing health problems like obesity and high blood pressure.

"The pandemic itself came under control, but the disparities that came with it continued and lingered," said Dr. Nasim Maleki, a psychiatry professor at Harvard Medical School.

The findings, published in JAMA Network Open, based on death certificates from across the US showed that between 2018 and 2022, deaths from alcohol-associated liver disease (ALD) rose nearly 9 per cent a year. Between 2006 and 2018, ALD deaths stood at 3.5 per cent per year.

While men still had the highest number of deaths -- 17 per 100,000 people -- women's death rates grew faster.

The Israel Defence Forces (IDF) on Saturday accused the Iranian media of "spreading lies" while terming reports about the downing of two Israeli F-35 fighter jets as "fake news".

Iran on Saturday claimed that the air defence force of its army has successfully shot down and destroyed two Israeli F-35 fighter jets and a large number of other micro air vehicles.

IDF's international spokesperson, Lieutenant Colonel Nadav Shoshani took to social media, labelling it as a "complete FAKE NEWS".

"While the Iranian regime spreads lies, we're taking down real threats like this Iranian UAV shot down over northern Israel this morning," he posted on X along with a video of Israeli defence forces downing an Iranian Unmanned Aerial Vehicle.

Foreign portfolio investors (FPIs) brought in Rs 3,346.94 crore into the Indian stock markets this week, as investor confidence received a strong boost following the Reserve Bank of India's (RBI) rate cut.

According to data from the National Securities Depository Limited (NSDL), FPIs were active buyers in the Indian equity market during the first three trading sessions of the week -- from June 9 to June 13.

The positive mood in the market was largely driven by the RBI’s decision to reduce the repo rate by 50 basis points to 5.5 percent, a move that many saw as a clear signal to support economic growth and improve market liquidity.

Market experts believe that this surprise rate cut has played a big role in attracting foreign investments, as it reflects a pro-growth approach from the central bank.

Low-cost Indian airline SpiceJet on Saturday announced that its revenue from operations fell 16 per cent year-on-year (YoY) to Rs 1,446.37 crore in Q4 FY25, down from Rs 1,719.3 crore in the corresponding quarter of FY24 (Q4 FY24).

However, the budget carrier’s profit soared nearly three times as profit after tax (PAT) rose to Rs 324.87 crore from Rs 119 crore in the year-ago quarter (Q4 FY24).

The company credited this turnaround to better passenger yields, strong load factors, and cost optimisation.

For the full financial year 2024-25, SpiceJet recorded a profit of Rs 580.74 crore, a remarkable recovery from the loss of Rs 409 crore in FY24.

However, annual revenue from operations declined by 25 per cent, dropping to Rs 5,284 crore compared to Rs 7,050 crore in the previous fiscal.