The CRISPR/Cas9 gene-editing technique has shown promise in fighting advanced colorectal cancer, according to results of the first-in-human clinical trial published in The Lancet Oncology.

The trial shows encouraging signs of the safety and potential effectiveness of the treatment against metastatic gastrointestinal (GI) cancers.

In the study, researchers used CRISPR/Cas9 gene-editing to modify a type of immune cell called tumour-infiltrating lymphocytes (TILs).

They deactivated a gene called CISH and found that modified TILs were better able to recognise and attack cancer cells.

"Despite many advances in understanding the genomic drivers and other factors causing cancer, with few exceptions, stage IV colorectal cancer remains a largely incurable disease," said Emil Lou, a gastrointestinal oncologist with the University of Minnesota Medical School.

Federal elections voting is underway in Australia as millions cast their votes, along with Prime Minister Anthony Albanese and Opposition Leader Peter Dutton.

PM Albanese of the left-leaning Australian Labor Party has cast his vote in Grayndler in Sydney.

When asked whether he would win the booth, he said, "Marrickville West is my local hood. If we don't win this booth, we're in real trouble."

Albanese is hoping to make history by becoming the first Prime Minister in 21 years to win consecutive elections.

"Voting for lower taxes, stronger Medicare, affordable housing and 20 per cent off your student debt. Voting Labor," Albanese posted on X after casting his vote.

According to the Australian Broadcasting Corporation, the latest Newspoll, published in The Australian, will give Albanese a reason to be optimistic, putting Labor ahead of the Liberal-National coalition (52.5 - 47.5 per cent after preferences).

The government on Saturday said that the committee constituted for the Framework on Repairability Index (RI) in mobile and electronic sector has submitted its report, to help consumers who witness issues while seeking repair for their devices.

The panel has submitted its report to Nidhi Khare, Secretary, Department of Consumer Affairs. The committee’s recommendations have been framed in alignment with the best global practices without causing any impediment to the industry with regard to innovation and ease of doing business.

The original equipment manufacturers (OEMs) are required to self-declare the Repairability Index based on a standards scoring criteria provided in the framework with no additional compliance burden, said Ministry of Consumer Affairs.

Actor Vijay Varma, who has completed filming for his upcoming project Matka King, described the experience as one of the most immersive of his career. He shared, it has been an incredible journey and added that he has never been this deeply involved in a story or lived with a character for such a long time.

Known for his layered performances, Vijay, who hinted that Matka King will showcase a new dimension of his craft, took to Instagram, where he shared a string of pictures from the wrap up celebrations with his co-star Kritika Kamra and others.

“Matka King wrapped! Never been so immersed in a story/character for this long. It’s been a great journey… You’ll all get to witness it when it releases on @primevideoin… Big love to the entire crew.”

Vijay also penned a line for Nagraj Manjule, who has helmed projects such as "Sairat" and "Fandry".

Actress Neha Sharma has wrapped up her schedule for her upcoming Punjabi film “Sanjog” in Manali, Himachal Pradesh.

Neha share a delightful series of pictures from her time in Himachal Pradesh. Her post offered a scenic journey—from behind-the-scenes moments on set and stunning views of snow-capped mountains to the breathtaking panorama from her hotel room.

She also included heartwarming videos of the film crew celebrating after wrapping up, along with snapshots of vibrant herself and local flowers that added a touch of charm to her experience.

“Which team are you on - Pahadon wali Maggie ya chai? #schedulewrap #sanjog #highupinthesky,” she wrote as the caption.

Karnataka Police have detained eight suspects in connection with the murder of Hindu activist Suhas Shetty, which was reported from the communally-sensitive city of Mangaluru, officials said on Saturday.

Police sources stated that the department is likely to formalise the arrests and make an official announcement later on Saturday.

The police had formed five special teams to apprehend the killers. All the accused are being interrogated, and they were arrested from various locations within Mangaluru district. Investigators have obtained video footage of the incident, which helped in identifying and apprehending the suspects, sources said.

However, Leader of the Opposition (LoP), R. Ashoka, alleged that a week before the murder, Suhas Shetty was warned by police not to carry weapons in his vehicle, and his vehicle was searched.

Benchmark indices ended with marginal gains in a highly volatile session on May 2 and volatility is expected to stay elevated due to ongoing geopolitical tensions, developments related to tariffs, and the unfolding Q4 earnings season and major US economic data points, analysts said on Saturday.

The Nifty on Friday opened strong and surged to an intraday high of 24,589 in the first half of the session. However, profit booking at higher levels erased those gains, leaving the index to close nearly flat.

The Nifty finished the day up 12.50 points, or 0.05 per cent, at 24,346.70.

“For the week, the BSE Sensex gained 1.6 per cent, while the Nifty50 rose 1.2 per cent. The BSE Midcap index declined 0.4 per cent and the Smallcap index ended flat,” said a note from Bajaj Broking Research.

Among sectoral performers, media, energy, IT, and oil & gas posted gains of 0.3–0.7 per cent. On the other hand, power, metal, telecom, pharma, realty, and consumer durables sectors saw losses ranging from 0.5 to 2 per cent.

Actress Priya Bapat said that the biggest reason to say yes to “Costao” was getting the opportunity to work with acclaimed star Nawazuddin Siddqui.

“Getting the opportunity to work with Nawaz sir was one of the biggest reasons I said yes to Costao,” said Priya, who plays Mariya, a strong and emotionally layered character in the film.

Priya said that she is a fan of Nawazuddin’s work on screen.

“I’ve been a fan of his work — his honesty on screen, the characters he chooses, and his complete commitment to the craft are deeply inspiring. To work so closely with him, to observe him up close, and to play his wife in the film was an incredible learning experience,” said Priya.

The actress added that there’s a sense of raw truth in the way he approaches scenes.

Saudi Pro League side Al-Hilal announced on Saturday that they have parted ways with Portuguese manager Jorge Jesus.

The decision comes just days after Al-Hilal was knocked out of the Asian Champions League Elite semifinals following a 3-1 loss to Al-Ahli.

With five matches left in the league season, Al-Hilal currently sits second in the standings, six points behind leaders Al-Ittihad. The club is also set to compete in the expanded Club World Cup in the United States this June and July.

"The Board of Directors of Al-Hilal Club Company has agreed with the Portuguese head coach of the first team Jorge Jesus to terminate the contractual relationship between them", Al-Hilal said in a statement on X.

"The Board expressed its appreciation for the efforts made by the technical staff since last season."

The US is experiencing a sharp resurgence of measles, with 935 confirmed cases reported so far this year -- more than triple the total for all of 2024, according to the latest data by the US Centers for Disease Control and Prevention (CDC).

A total of 12 measles outbreaks have been recorded nationwide this year. The CDC defines an outbreak as three or more connected cases, news agency reported.

This year's case count represents a significant surge from 2024 when 285 measles cases were recorded in the country for the entire year.

The CDC emphasises that the best way to prevent measles is through vaccination. Two doses of the MMR (measles, mumps, rubella) vaccine are highly effective in preventing the disease.